Ingredients
| Bacopa monnieri extract | 300.00 mg |
| Ginkgo biloba extract | 125.00 mg |
| Ginseng extract | 150.00 mg |
| Centella asiatica extract | 120.00 mg |
| Sage extract | 90.00 mg |
| Polygala tenuifolia root extract | 105.00 mg |
| Melissa officinalis extract | 105.00 mg |
| Microencapsulated caffeine from coffee beans | 83.33 mg |
| thereof Caffeine | 75.00 mg |
| Curcuma longa extract | 63.16 mg |
| Green tea extract | 60.00 mg |
| Sophora japonica extract (95% Quercetin) | 47.37 mg |
| Resveratrol | 30.00 mg |
| Saffron extract (2% saffranal) | 30.00 mg |
| Huperzia serrata extract (1% huperzin A) | 15.00 mg |
Capsule shell: Hydroxypropyl methylcellulose
Bacopa monnieri extract
Bacopa monnieri also known as Brahmi, water hyssop or Indian pennywort is a plant native to several varied climates including India, Australia, Europe, and parts of America.
Its name is said to stem from the word Brahman that meaning “universal mind”, which perfectly illustrates the main effect of the plant. Allegedly, ancient Vedic scholars used Bacopa monnieri to better memorize lengthy sacred hymns and scriptures.
Ayurvedic practitioners classify it as a medhya rasayana – an herb taken to sharpen the intellect and improve mental deficits.
In other words, Bacopa monnieri is probably one of the oldest-known nootropics in the world. This plant is a great natural memory enhancer.
Bacopa monnieri is an enormous support for the nervous system. In particular, it stimulates the part responsible for memory processes. Thanks to that, it clearly improves intellectual functions and the organism’s cognitive processes, as well as contributes to the improvement of memory and concentration. Using Bacopa monnieri regularly perfects the speed of visual information processing, remembering new information and verbal learning.
The herb contains a mix of synergistic compounds. Some are unique to it, like brahmine, but its most important active compounds are its bacosides. These plant compounds are responsible for improving learning and memory. They could protect the brain, scavenge free radicals, and increase acetylcholine – the most important neurotransmitter for memory and learning.
Research suggest that Bacopa monnieri works by promoting neuron dendrite growth – the communication channels of human neurons. Better inter-neuronal communications mean better focus, faster memory formation, and quicker memory recall.
Since Bacopa monnieri improves memory function in healthy and young people it would be particularly effective in older people suffering with age-related memory loss.
In several clinical trials, Bacopa monnieri has been found to improve memory retention, recall speed, and recall accuracy in people living with age-related memory impairment.
Studies reported the efficacy of Bacopa monnieri on cognitive performance, anxiety, and depression in the elderly and found effective in enhancing cognitive functions in the elderly. This explains its use as a memory enhancer.
Another study demonstrated that Bacopa monnieri inhibits cholinergic degeneration and exhibits cognition enhancing activity in persons with Alzheimer’s disease.
Ginkgo biloba extract
Ginkgo biloba is one of the most ancient tree species on Earth, known with healing properties on its leaves. It has been used in Traditional Medicine for centuries because it has a beneficial effect on memory, heart, blood vessels, and blood pressure.
A number of studies have shown that standardized Ginkgo biloba extract (containing 24% flavonoid glycosides and 6% terpenoid lactones) improves blood circulation, especially to the brain and limbs, effectively affects the individual’s memory and slows down the aging of the brain.
The extract has been shown to help supply brain cells with glucose, which is vital for the proper functioning of the brain and central nervous system. At the same time, the extract improves the transmission of nerve signals between brain cells and thus further stimulates brain function and helps to enhance memory.
The combination of flavonoids and trilactones promotes blood circulation not only in the central but also in the peripheral circulatory system, which means that blood and nutrients are improved in the eyes, ears and other important sensory organs. This also improves limb irrigation.
Ginkgo biloba is a powerful antioxidant that has an effect on the whole body, improves thinking and memory, slows down brain aging, reduces fatigue, increases concentration and performance and protecting cells from alteration. According to recent studies, the herb also prevents and successfully combats Alzheimer’s disease.
Ginkgo biloba extract has shown favorable effects on cerebral circulation, neuronal cell metabolism, the cholinergic system; has antioxidant activity, reduces apoptosis, and is neuroprotective against NO‐ and β‐amyloid‐induced toxicity.
Ginkgo biloba extract contains a specific ingredient – ginkolic acid, which in high concentrations can cause gastric discomfort and allergic reactions. Its content in the extract is inevitable. It is important concentration of ginkolic acid not to exceed the safe dose of 5 ppm.
Ginseng extract
Ginseng is an excellent adaptogen and restorative agent that reduces the stress and tension and increases the body’s defenses. It is also known to improve memory, cognitive abilities and the overall tonus. Ginseng relieves nervous fatigue, helps with insomnia and nightmares, intense fear, forgetfulness, dizziness, impotence and exhaustion. Additionally, it has a positive effect with malignancies.
The active ingredient – ginsenosides – increase alertness and mental clarity and help with frequent mood swings.
Ginsenosides increased levels of dopamine and norepinephrine in the cerebral cortex and have beneficial effects on attention, cognitive processing, sensorimotor function and auditory reaction time in healthy people.
In addition, ginsenosides improve central cholinergic function, and are used to treat memory deficits in humans.
Numerous studies show that ginsenosides can reduce or prevent memory deficits associated with cholinergic function. Ginsenosides enhance acetylcholine (ACh) levels in the central nervous system, by increasing choline acetyltransferase (ChAT) activity or by inhibiting acetylhydrolase (AChE) activity.
By acting on the brain as a stimulant, ginseng can improve mental activity and ability to concentrate. As an antioxidant, it protects vulnerable brain cells from the free radicals. And this prevents memory loss and degenerative diseases.
Centella asiatica extract
Centella asiatica also known as Gotu Kola is a plant native to the Southeast Asia and has been used traditionally as brain tonic in Аyurvedic medicine.
In ancient China and India, Centella asiatica was used to strengthen and stimulate the brain and slow down the aging process. The herb revitalizes the brain and nervous system, increases attention and concentration, fights aging, reduces headaches, helps the body to overcome nervous tension. Centella asiatica further stimulates the immune system.
Centella asiatica reverse the amyloid beta (Aβ) pathology and reduced oxidative stress response. Amyloid beta is the main component of amyloid plaques, extracellular deposits found in the brains of people with Alzheimer’s disease.
Centella asiatica is considered one of the most powerful adaptogens in the world, supporting the normal functioning of the nervous system. Supports CNS functions and brain activity by supporting blood circulation to the brain and irrigation. Helps to relieve mental fatigue, tone the brain and promoting longevity.
Sage extract
The botanical name of the herb Sage (Salvia officinalis L.) comes from salvare, which in Latin means “to heal.”
The Sage is an aromatic plant used since ancient times to treat numerous health issues. In the Middle Ages it was the main ingredient in potions blended by healers and alchemists for good memory and longevity.
Sage has anti-inflammatory and antibacterial properties, stimulates blood circulation, and dilates blood vessels.
Sage contains a large number of phytochemicals which have a vast array of biological activities, many of them relevant to disorders of the central nervous system.
Sage has long been famous to enhance memory and mental function in both younger and older adults and for restoring memory in old age.
Sage can help support the brain and memory in several ways. For one, it’s loaded with compounds that can act as antioxidants, which have been shown to buffer the brain’s defense system. It also appears to halt the breakdown of the chemical messenger acetylcholine (ACH), which has a role in memory (ACH levels fall in Alzheimer’s disease).
Studies show that sage may improve memory, brain function and symptoms of Alzheimer’s disease. The Sage has positive effects on mental performance, memory, mood, attention and brain function in both younger and older adults.
Polygala tenuifolia root extract
Polygala tenuifolia is a Traditional Chinese Medicine plant that is also known as Yuan Zhi with many health benefits.
Traditional Chinese Medicine defines Polygala tenufolia as a neuroprotective agent. It is one of the three most common plants used for memory enhancement in Traditional Chinese Medicine. Polygala tenufolia has a history of being used by Buddhist monks for enhanced cognition and focus during meditation.
Polygala root benefits memory and cognitive function, promotes a positive mental state, supports natural sleep, and benefits skin health. Polygala tenufolia has anti-inflammatory properties and can be useful in reducing inflammation in neurodegenerative diseases.
The studies have demonstrated that Polygala tenufolia inhibited the secretion and formation of amyloid beta plaques – one of the mechanisms behind Alzheimer’s Disease is the formation of toxic plaques formed by amyloid beta peptides (also known as amyloid beta plaques).
The studies demonstrated that Polygala tenuifolia and its active components have multiplex neuroprotective potential associated with Alzheimer’s disease, such as anti-Aβ aggregation, anti-Tau protein, anti-inflammation, antioxidant, anti-neuronal apoptosis, enhancing central cholinergic system and promote neuronal proliferation.
The studies focused on this plant concluded that the extract of Polygala tenufolia root enhanced memory and cognitive functions in healthy adults and in elderly adults.
Withania Somnifera extract
Withania somnifera also known as Ashwagandha has long been used in the Traditional Ayurvedic system to enhance memory, improve cognition and overall brain functioning.
Withania somnifera has been used to promote physical and mental health, to provide defense against disease and adverse environmental factors, and to arrest the aging process.
Withania somnifera shows a significant improvement in cognitive ability and memory, improved attention, concentration and information processing time. It has a cognition promoting effect and was found to be useful in people with memory deficit and old age people with memory loss.
The studies have shown that Withania somnifera extract improve the cognitive and psychomotor performance in healthy humans and confirm its therapeutic efficacy in disease states associated with impaired cognition and psychomotor function.
Memory enhancing activity and cognition improving property of Withania somnifera are due to its ability to increase acetylcholine level in the brain.
These results suggest that Withania somnifera extract can be a valuable adjunct in the treatment of diseases associated with cognitive impairments.
Melissa officinalis extract
Melissa officinalis has a documented medicinal history extending back to the ‘Materia Medica’ in approximately 50–80 BC.
Melissa officinalis (Lemon balm) is a herbal medicine that has traditionally been attributed with memory-enhancing properties, but which is used more widely as a mild sedative and sleep aid.
Melissa officinalis has been frequently used in Iranian Traditional medicine to treat neurological disorders such as depression and anxiety, and it is also mentioned as a memory enhancing herb.
The studies show that Melissa officinalis extract and its main constituent rosmarinic acid can improve cognitive performance and mood and may therefore be a valuable adjunct in the treatment of Alzheimer’s disease.
Extract of Melissa officinalis had an anticholinesterase activity and potent antioxidant properties with promising potential in Alzheimer’s disease treatment.
Melissa officinalis is also found to exhibit antioxidant, anti-inflammatory, anxiolytic, antidepressant, and neuroprotective effects, all of which are key elements in Alzheimer’s disease management.
Microencapsulated caffeine from coffee beans
Caffeine acts as a stimulant to the central nervous system. One of the most well-known caffeine abilities is the ability to improve concentration, especially in fatigue.
Caffeine has a beneficial effect on both short-term and long-term memory. Caffeine improve attention, concentration and focus, increase wakefulness, alleviate fatigue and it also enhances working memory. It not only increases alertness, caffeine can improve mood and even reduce the risk of depression.
Caffeine contains polyphenol antioxidants and affects adenosine receptors in the brain. It stimulates the production of dopamine and glutamine, which are natural brain-stimulating energizers that keep us alert and uplifting.
Studies have found that caffeine consumption may help enhance some thinking skills and slow the mental decline that comes with age and also may reduce the risk of developing Alzheimer’s disease.
Curcuma longa extract
Turmeric (Curcuma longa L.) is the major source of curcumin which has been extensively investigated for its therapeutic efficacy in various disorders.
Turmeric contains curcuminoids which has anti-oxidative and neuro-protective effects. Curcuminoids have a number of brain health benefits, which include supporting mood, memory and overall cognitive function.
Many researches show that curcumin can improve memory and attention in older adults. Curcumin has a positive impact on cognitive health-supporting memory, attention and mood in healthy, middle-aged or older adult.
Turmeric may be considered as a therapeutic alternative in the control of the aging process with the main aim of improving the quality of life of elderly people. Furthermore, long-term turmeric use was found to improve behavioral and psychological symptoms of dementia and prevent associated exacerbations.
Curcuminoids have a high potential in the treatment of Alzheimer’s disease because of their ability to break down β-amyloid plaques. The results of several studies illustrate the ability of curcuminoids to modulate β-amyloid aggregation, regulate its production, interfere with its neurotoxic effects, and aid in its clearance together with improvements in cognition, memory, behavioral and psychiatric symptoms; therefore, curcuminoids have a high potential in the treatment of Alzheimer’s disease.
Green tea extract
Green tea leaves (Camellia sinensis) contain caffeine and are rich in antioxidants and polyphenols. The anti-tumor immunomodulatory effects of green tea and its polyphenols, called catechins, including epicatechin, epicatechin gallate, epigallocatechin and epigallocatechin gallate (ECGC) have been well studied. Catechins have an amazing health effect in cardiovascular disease, as well as a preventative effect against cell degeneration. They improve age-related cognitive decline.
Due to its powerful antioxidant properties, Green tea provide strong protective effects for the brain and impedes the development of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
Researchers have reported EGCG spurs the creation of brain cells in the hippocampus – the primary structure in the brain responsible for processing information from short-term memory and long-term memory.
Researchers in Switzerland found that Green tea extract increased Interconnection between frontal and parietal brain cells. This increased activity resulting in a heightened ability to recall information and correlated with improved performance on the working memory tasks.
The Green tea extract has been shown to block harmful proteins in Alzheimer’s disease that cause memory loss.
These results show that Green tea extract could be promising in the treatment of cognitive impairments associated with neuropsychiatric disorders, such as dementia.
Sophora japonica extract (95% Quercetin)
Sophora japonica, otherwise known as Japanese pagoda tree, is native to eastern China and Japan.
Sophora japonica is one of the fifty fundamental herbs in Traditional Chinese Medicine and has a documented history of being used to support circulatory system health.
Sophora japonica contains a range of highly active and beneficial phytonutrients which exhibit strong antioxidant activity. Antioxidants such as quercetin and rutin scavenged free radicals, slows down aging, which reduces the rate of memory loss associated with changes in age.
Sophora japonica extract has a high potential in for the prevention and treatment of neurodegenerative disorders and improvement of cognitive functions.
Resveratrol
Resveratrol is a polyphenolic compound, powerful antioxidant with various beneficial health effects.
Recent studies show that resveratrol strengthens and protects one of human most important organs, the brain. Brain cells require a constant supply of oxygen to function properly, and resveratrol significantly increases blood flow to the brain and improves its oxygen supply.
Other studies show that resveratrol can help fight accelerated cell degeneration, which reduces the chance of developing diseases such as dementia, Alzheimer’s disease and prevents mental health issues such as depression, bipolar disorder and more.
Resveratrol has potent antioxidant activity that has a role in preventing neurodegeneration in Alzheimer’s disease. Particularly, it scavenges free radicals, protects neurons and microglia and attenuates Aβ-induced intracellular reactive oxygen species accumulation.
Saffron extract (2% Safranal)
Saffron is the dried stigma of the Crocus sativus plant native to the Middle East. It is a spice with a strong fragrance and distinctive color.
The majority of the saffron’s health claims relate to its high levels of specific antioxidants like safranal, crocin and picrocrocin. Safranal and crocin are unique carotenoids in Saffron make it a potent antioxidant. The antioxidants in saffron play a role in protecting the body from disorders affecting the nervous system because scavenging free radicals reduces inflammation, preventing apoptosis, and protecting brain cells and mitochondria.
Saffron boosts brain health and function. It has a beneficial impact on learning, concentration, memory, and age-related mental impairment.
The studies found that saffron improved cognitive function, brain signaling and help learning and memory in people with mild to moderate Alzheimer’s disease.
Saffron inhibits the deposit of amyloid-β which is associated with the progression of Alzheimer’s disease. Saffron also inhibits the breakdown of acetylcholine (acetylcholinesterase) just like the current medication (donepezil) approved to treat Alzheimer’s.
Saffron extract inhibit the uptake of dopamine and norepinephrine in the brain which helps improve mood and increase libido.
The studies show that saffron may support healthy levels of serotonin in the brain, a neurotransmitter that contributes to feelings of happiness and well-being and could be an alternative to some popular antidepressant medications.
Huperzia serrata extract (1% Huperzinе A)
Huperzia serrata is also known as Chinese club moss has been used in Traditional Chinese Medicine for treating and preventing memory loss. It is used as a component in traditional Chinese herbal formulas to improve blood circulation and to relieve pain.
A purified alkaloid extract from this plant known as Huperzine A has neuroprotective effects and has been developed as a treatment for Alzheimer’s disease and dementia in Asia.
Huperzine A is a potent anti‐AChE alkaloid, which has neuroprotective effects related to its ability to attenuate oxidative stress, regulate the expression of apoptotic proteins, protect mitochondria, and modulate amyloid precursor protein (APP) metabolism.
Clinical studies showed that Huperzine A may benefit people with Alzheimer’s disease and also improve cognition in people with vascular dementia.
It can be used as an adjunct in healthy individuals as well as adults to support cognitive ability and mental potential in general.
MEMOSTORM
MEMOSTORM provides strong memory support, promotes mental abilities, brain cell regeneration and well-being.
MEMOSTORM is a food supplement extracted from natural products.
MEMOSTORM is a food supplement registered in the EU and Switzerland.
Scientific publications:
1. Vollala V, Upadhya S, Nayak S. Enhanced dendritic arborization of hippocampal CA3 neurons by Bacopa monniera extract treatment in adult rats, 2011;52(3):879-86.
2. Vollala V, Upadhya S, Nayak S. Enhancement of basolateral amygdaloid neuronal dendritic arborization following Bacopa monniera extract treatment in adult rats, 2011 Apr; 66(4): 663–671.
3. Calabrese C, Gregory W, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial, 2008 Jul;14(6):707-13.
4. Stough C, Downey L, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan P. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial, 2008 Dec;22(12):1629-34.
5. Stough C, Lloyd J, Clarke J, Downey L, Hutchison C, Rodgers T, Nathan P. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects, 2001 Aug;156(4):481-4.
6. Raghav S, Singh H, Dalal P, Srivastava J, Asthana O, Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment, 2006 Oct;48(4):238-42. doi: 10.4103/0019-5545.31555.
7. Aguiar S, Borowski Th, Neuropharmacological Review of the Nootropic Herb Bacopa monnieri, 2013 Aug; 16(4): 313–326.
8. Simpson T, Pase M, Stough S, Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain, 2015; 2015: 615384.
Scientific publications:
1. Mahadevan S, Park Y. Multifaceted therapeutic benefits of Ginkgo biloba L.: chemistry, efficacy, safety, and uses. J Food Sci. 2008; 73(1):R14-R19.
2. Amieva H, Meillon C, Helmer C, Barberger-Gateau P, Dartigues JF. Ginkgo biloba extract and long-term cognitive decline: A 20-year follow-up population-based study. PLoS One. 2013; 8(1):52755.
3. Liu X, Hao W, Qin Y, Decker Y, Wang X, Burkart M, et al. Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer’s disease. Brain Behav Immun. 2015; 46:121-31.
4. Müller WE, Eckert A, Eckert GP, Fink H, Friedland K, Gauthier S et al. Therapeutic efficacy of the Ginkgo special extract EGb761® within the framework of the mitochondrial cascade hypothesis of Alzheimer’s disease. World J Biol Psychiatry. 2017: 1-7.
5. Zhang LD, Ma L, Zhang L, Dai JG, Chang LG, Huang PL et al. Hyperbaric Oxygen and Ginkgo biloba Extract Ameliorate Cognitive and Memory Impairment via Nuclear Factor Kappa-B Pathway in Rat Model of Alzheimer’s Disease. Chin Med J. 2015; 128(22):3088- 3093.
6. Napryeyenko O, Borzenko I. Ginkgo biloba special extract in dementia with neuropsychiatric features: A randomised, placebo-controlled, double-blind clinical trial. Arzneimittelforschung 2007;57:4–11.
7. Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007.
8. Singh S, Srivastav S, Castellani R, Villa G, Perry G. Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders, 2019 Jul; 16(3): 666–674.
Scientific publications:
1. Cheng Y, Shen LH, Zhang JT. Anti-amnesic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacol Sin 2005;26:143–149.
2. Nah S-Y, Kim D-H, Rhim H. Ginsenosides: Are any of them candidates for drugs acting on the central nervous system? CNS Drug Rev 2007;13:381–404.
3. Lee MS, Yang EJ, Kim JI, Ernst E. Ginseng for cognitive function in Alzheimer’s disease: A systematic review. J Alzheimers Dis 2009;18:339–344.
4. Hwang SH, Shin EJ, Shin TJ, Lee BH, Choi SH, Kang J et al. Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer’s disease-related neuropathies: involvement of non-amyloidogenic processing. J Alzheimers Dis. 2012; 31(1):207-223.
5. Kim H, Jung S, Kim S, Cho I, Kim H, Rhim H, Kim M, Nah S. Panax ginseng as an adjuvant treatment for Alzheimer’s disease, 2018 Oct; 42(4): 401–411.
6. Kim J, Kim SH, Lee DS, Lee DJ, Kim SH, Chung S et al. Effects of fermented ginseng on memory impairment and β-amyloid reduction in Alzheimer’s disease experimental models. J Ginseng Res. 2013; 37(1):100-107.
7. Li H, Kang T, Qi B, Kong L, Jiao Y, Cao Y et al. Neuroprotective effects of ginseng protein on PI3K/Akt signaling pathway in the hippocampus of d- galactose/AlCl 3 inducing rats model of Alzheimer’s disease. J Ethnopharmacol. 2016; 179:162-169.
Scientific publications:
1. Orhan IE. Centella asiatica (L.) Urban: from traditional medicine to modern medicine with neuroprotective potential. Evid Based Complementary Altern Med. 2012.
2. Chen CL, Tsai WH, Chen CJ, Pan TM. Centella asiatica extract protects against amyloid b1e40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system. J Tradit Complement Med. 2015:1-8.
3. Gray NE, Harris CJ, Quinn JF, Soumyanath A. Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice. J Ethnopharmacol. 2016; 180:78-86.
4. Gray NE, Zweig JA, Murchison C, Caruso M, Matthews DG, Kawamoto C et al. Centella asiatica attenuates Aβ- induced neurodegenerative spine loss and dendritic simplification. Neuroscience Letters. 2017; 646:24-29.
5. Wattanathorn J, Mator L, Muchimapura S, Tongun T, Pasuriwong O, Piyawatkul N, Yimtae K, Sripanidkulchai B, Singkhoraard J. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica, 2008 Mar 5;116(2):325-32.
Scientific publications:
1. Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi AH, Khani M et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: A double blind, randomized and placebo‐controlled trial. J Clin Pharm Ther. 2003; 28(1):53-59.
2. Sallam A, Mira A, Ashour A, Shimizu K. Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis. Phytomedicine. 2016; 23(10):1005- 1011.
3. Scholey AB, Tildesley NT, Ballard CG, Wesnes KA, Tasker A, Perry EK, Kennedy DO. An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers. Psychopharmacology 2008;198:127–139.
4. Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi AH, Khani M. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: A double blind, randomized and placebo-controlled trial. J Clin Pharm Ther 2003;28:53–59.
5. Iuvone T, De Filippis D, Esposito G, D’Amico A, Izzo AA. The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-β peptide-induced neurotoxicity. J Pharmacol Exp Ther 2006;317:1143–1149.
6. Eidi M, Eidi A, Bahar M. Effects of Salvia officinalis L. (sage) leaves on memory retention and its interaction with the cholinergic system in rats. Nutrition 2006;22:321–326.
Scientific publications:
1. Deng X, Zhao S, Liu X, Han L, Wang R, Hat H, Jiao Y, Han S, Bai C. Polygala tenuifolia: a source for anti-Alzheimer’s disease drugs, 2020; 58(1): 410–416.
2. Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. China: People’s Medical Publishing House, 2005.
3. Shin K, Lee J, Won B, Jung H. BT-11 is effective for enhancing cognitive functions in the elderly humans, Neuroscience Letters 465(2):157-9
Scientific publications:
1. Choudhary D, Bhattacharyya S, Bose S. Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions, 2017 Nov 2;14(6):599-612.
2. Singh N, Bhalla M, Jager P, Gilca M. An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda, 2011; 8(5 Suppl): 208–213.
3. Pingali U, Pilli R, Fatima N. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants, 2014 Jan-Mar; 6(1): 12–18.
4. Akram M, Nawaz A. Effects of medicinal plants on Alzheimer’s disease and memory deficits, 2017 Apr; 12(4): 660–670.
5. Tohda C, Kuboyama T, Komatsu K. Search for natural products related to regeneration of the neuronal network. Neurosignals 2005;14:34–45.
1. Miraj S, Kopaei R, Kiani S. Melissa officinalis L: A Review Study With an Antioxidant Prospective, 2017 Jul; 22(3): 385–394.
2. Kennedy DO, Scholey AB. The psychopharmacology of European herbs with cognition-enhancing properties. Curr Pharm Des 2006;12:4613–4623.
3. Perry E, Howes M. Medicinal Plants and Dementia Therapy: Herbal Hopes for Brain Aging?, 2011 Dec; 17(6): 683–698.
4. Soodi M, Naghdi N, Hajimehdipoor H, Choopani S, Sahraei E. Memory-improving activity of Melissa officinalis extract in naïve and scopolamine-treated rats, 2014 Mar-Apr; 9(2): 107–114.
Scientific publications:
1. Arendash GW, Cao C. Caffeine and coffee as therapeutics against Alzheimer’s disease. J Alzheimers Dis 2010;20:S117–S126.
2. Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife coffee and tea drinking and the risk of late-life dementia: A population-based CAIDE study. J Alzheimers Dis 2009;16:85–91.
3. What does caffeine do to your body?, Medical News Today
4. Tohda C, Kuboyama T, Komatsu K. Search for natural products related to regeneration of the neuronal network. Neurosignals 2005;14:34–45.
1. Hishikawa N, Takahashi Y, Amakusa Y, Tanno Y, Tuji Y, Niwa H et al. Effects of turmeric on Alzheimer’s disease with behavioral and psychological symptoms of dementia. Ayu. 2012; 33(4):499-504.
2. Veldman ER, Jia Z, Halldin C, Svedberg MM. Amyloid binding properties of curcumin analogues in Alzheimer’s disease postmortem brain tissue. Neurosci Lett. 2016; 630:183-188
3. Goozee KG, Shah TM, Sohrabi HR, Rainey-Smith SR, Brown B, Verdile G, et al. Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease. Br J Nutr. 2016; 115(3):449-65.
4. Sun AY, Wang Q, Simonyi A, Sun GY. Botanical phenolics and brain health. Neuromolecular Med 2008;10:259–274.
5. Frank B, Gupta S. A review of antioxidants and Alzheimer’s disease. Ann Clin Psych 2005;17:269–286.
6. Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem 2008;114:127–149.
1. Frank B, Gupta S. A review of antioxidants and Alzheimer’s disease. Ann Clin Psych 2005;17:269–286.
2. Sun AY, Wang Q, Simonyi A, Sun GY. Botanical phenolics and brain health. Neuromolecular Med 2008;10:259–274.
3. Unno K, Hoshino M. Brain senescence and neuroprotective dietary components. Cent Nerv Syst Agents Med Chem 2007;7:109–114.
4. Schmidt A, Hammann F, Wölnerhanssen B, Gerspach A, Drewe J, Beglinger C, Borgward S. Green tea extract enhances parieto-frontal connectivity during working memory processing, 2014; 231(19): 3879–3888.
5. University of Basel. “Green tea extract boosts your brain power, especially the working memory, new research shows.” ScienceDaily. ScienceDaily, 7 April 2014.
1. He X, Bai Y, Wang X. Local and traditional uses, phytochemistry, and pharmacology of Sophora japonica L.: A review, April 2016 Journal of Ethnopharmacology 187.
2. PHARMACEUTICAL COMPOSITION CONTAINING SOPHORA JAPONICA L. EXTRACT AS ACTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS, 25.08.2016, 20190231835.
3. Syad AN, Devi KP. Botanics: a potential source of new therapies for Alzheimer’s disease?. Botanics: Targets and Therapy. 2014;4:11-26
1. Sun AY, Wang Q, Simonyi A, Sun GY. Botanical phenolics and brain health. Neuromolecular Med 2008;10:259–274.
2. Frank B, Gupta S. A review of antioxidants and Alzheimer’s disease. Ann Clin Psych 2005;17:269–286.
3. Rocha-Gonza ́lez HI, Ambriz-Tututi M, Granados-Soto V. Resveratrol: A natural compound with pharmacological potential in neurodegenerative diseases. CNS Neurosci Ther 2008;14:234–247.
4. Tellone E, Galtieri A, Russo A, Giardina B, Ficarra S. Resveratrol: A Focus on Several Neurodegenerative Diseases, 2015; 2015: 392169.
5. Rege S, Geetha T, Griffin G, Broderick T, Babu J. Neuroprotective effects of resveratrol in Alzheimer disease pathology, 014; 6: 218.
1. Howes M-JR, Perry NSL, Houghton PJ. Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytother Res 2003;17:1–18.
2. Pitsikas N. The Effect of Crocus sativus L. and Its Constituents on Memory: Basic Studies and Clinical Applications, 2015; 2015: 926284.
3. Akhondzadeh S, Shafiee Sabet M, Harirchian MH, et al. A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease. Psychopharmacology 2010;207:637–643.
4. Adalier N, Parker H. Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease, 2016 Dec; 5(4): 40.
1. Wang R, Tang XC. Neuroprotective effects of huperzine A. A natural cholinesterase inhibitor for the treatment of Alzheimer’s disease. Neurosignals 2005;14:71–82.
2. Wang BS, Wang H, Wei ZH, Song YY, Zhang L, Chen HZ. Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer’s disease: An updated meta-analysis. J Neural Transm 2009;116:457–465.
3. Howes M-JR, Houghton PJ. Plants used in Chinese and Indian traditional medicine for improvement of memory and cognitive function. Pharmacol Biochem Behav 2003;75:513–527.